报告题目：Ab Initio Protein Structure Folding by QUARK

报告人：Dong Xu

时间：11月15日14：00

地点：校本部理工楼321室

报告摘要：Ab initio protein structure prediction is one of the hardest problems in computational structural biology, which requires the knowledge in different research areas. Due to the design of accurate statistical energy potentials and adequate random movements, QUARK ab initio folding program can successfully build the correct structural folds for most of the small globular proteins from scratch. It has been proved to be the best program for predicting template-free targets in the recent CASP9 and CASP10 competitions. The predicted models by QUARK are accurate enough for various applications such as molecular replacement, EM fitting and binding-site prediction.

个人简介：Dong Xu got his Ph.D degree from the Institute of Computing Technology, Chinese Academy of Sciences in 2008. He was the post-doc of professor Yang Zhang during 2008 and 2012, staying in the University of Kansas and then the University of Michigan. From 2012, he worked for Prof. Adam Godzik, director of Bioinformatics and System Biology Program at Sanford-Burnham Medical Research Institute. His major research area is molecular graphics, template-free protein structure folding and template-based fold recognition.